BET-inhibition by JQ1 promotes proliferation and self-renewal capacity of hematopoietic stem cells
نویسندگان
چکیده
منابع مشابه
Smad7 promotes self-renewal of hematopoietic stem cells.
The Smad-signaling pathway downstream of the transforming growth factor-beta superfamily of ligands is an evolutionarily conserved signaling circuitry with critical functions in a wide variety of biologic processes. To investigate the role of this pathway in the regulation of hematopoietic stem cells (HSCs), we have blocked Smad signaling by retroviral gene transfer of the inhibitory Smad7 to m...
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The Smad-signaling pathway downstream of the transforming growth factor– superfamily of ligands is an evolutionarily conserved signaling circuitry with critical functions in a wide variety of biologic processes. To investigate the role of this pathway in the regulation of hematopoietic stem cells (HSCs), we have blocked Smad signaling by retroviral gene transfer of the inhibitory Smad7 to murin...
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A single hematopoietic stem cell (HSC) can generate a clone, consisting of daughter HSCs and differentiated progeny, which can sustain the hematopoietic system of multiple hosts for a long time. At the same time, this massive expansion potential must be restrained to prevent abnormal, leukemic proliferation. We used an interdisciplinary approach, combining transplantation assays with mathematic...
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1Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA 2Department of Pathology and Laboratory Medicine, Stowers Institute for Medical Research, University of Kansas School of Medicine, Kansas City, MO 64110, USA 3Terry Fox Laboratory, British Columbia Cancer Agency and Department of Medicine, Unive...
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ژورنال
عنوان ژورنال: Haematologica
سال: 2018
ISSN: 0390-6078,1592-8721
DOI: 10.3324/haematol.2017.181354